Miltefosine - CAS# 58066-85-6 halomannine 000-fold selectivity over a large

000-fold selectivity over a large panel of human kinases

CAS Number: 211914-51-1

Adam Siddiqui-Jain

Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β

PMID: 22715131

Miltefosine - CAS# 58066-85-6 halomannine 000-fold selectivity over a largeMiltefosine is an orally and topically active alkyl phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti apoptotic mitogen activated protein kinase (MAPK) pathway and modulates