LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 423 (2009) Nature Methods 6

(2009) Nature Methods 6

Allele-specific p53 mutant reactivation

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Reprogramming of human primary somatic cells by OCT4 and chemical compounds

LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 423 (2009) Nature Methods 6LDN 193189, CAS No. 1062368 24 4, is a cell permeable, highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM), but not ALK4, ALK5, and ALK7 (> 0. 5 M). It prevents Smad1, Smad5, and Smad8 phosphorylation. It is a useful tool compound to modulate stem cell differentiation (for example, neural differentiation of human ESC iPSC in combination with SB431542). It was also used in animal